Special Chemical

Silane-PEG-Acrylate (Acrylate-PEG-Silane, Silane-PEG-Acrl, or Acrl-PEG-Silane)  is a linear heterobifunctional PEG reagent with an acrylate and a silane group. It is a useful crosslinking reagent with a PEG spacer. Acrylate can polymerize with UV light or radical initiator to form PEG hydrogel, and silane can react with glass or other hydroxylated surfaces.

• Silane-PEG-Biotin is a linear heterobifunctional PEG reagent with a biotin and an silane.
• It is a useful crosslinking or bioconjugation reagent with a PEG spacer.
• Biotin can bind to avidin and streptavidin with high specificity and affinity.  Silane can be used to react with glass, silica, or other hydroxylated particle surface.

Silaene-PEG-COOH is a linear heterobifunctional PEG reagent with silane and carboxylic acid.

Ethoxy silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Typically, the functionalization of silica, known as silanization, begins with APTES and involves multiple steps to produce the desired functionality. However, with methoxy, azide, alkyne, and biotin functionalities, NSP’s silane PEGs greatly reduces the steps required to create the desired functionality.

• Silane-PEG-DBCO is a linear heterobifunctional PEG reagent with a DBCO and a silane.
• It is a useful crosslinking or bioconjugation reagent with a PEG spacer.
• Silane can be used to react with glass, silica, or other hydroxylated particle surface.

DBCO (dibenzocycolctyne) PEG Silane derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

• Silane-PEG-Maleimide (Silane-PEG-Mal)  is a linear heterobifunctional PEG reagent with a maleimide and a silane.
• It is a useful crosslinking reagent with a PEG spacer. Maleimide reacts with thiol, SH, sulfhydryl or mercapto, and silane group can react with glass or other hydroxylated surface or particle.
• It may be used to introduce thiol or cysteine reactive functional group on hydroxylated nanopartilce, microsphere, self-assembled monolayer or metal chips.
•  Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Silaene-PEG-Amine (Silane-PEG-NH2)  is a linear heterobifunctional PEG reagent with silane and amine.

Ethoxy silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Typically, the functionalization of silica, known as silanization, begins with APTES and involves multiple steps to produce the desired functionality. However, with methoxy, azide, alkyne, and biotin functionalities, NSP’s silane PEGs greatly reduces the steps required to create the desired functionality.